PHYSICAL MAPPING WITHIN THE TUBEROUS SCLEROSIS LINKAGE GROUP IN REGION 9Q32-Q34

被引：26

作者：

HARRIS, RM ^{[1
]}

CARTER, NP ^{[1
]}

GRIFFITHS, B ^{[1
]}

GOUDIE, D ^{[1
]}

HAMPSON, RM ^{[1
]}

YATES, JRW ^{[1
]}

AFFARA, NA ^{[1
]}

FERGUSONSMITH, MA ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT PATHOL, TENNIS COURT RD, CAMBRIDGE CB2 1QP, ENGLAND

来源：

GENOMICS | 1993年 / 15卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1056

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pulsed-field gel electrophoresis and flow dot-blot analysis have been used to construct a physical map of the q32-q34 region of chromosome 9, where one of the loci responsible for tuberous sclerosis (TSC1) has been mapped by genetic linkage. Five linked groups of markers have been defined by pulsed-field gel electrophoresis. The orientation of these groups and the order of markers within them were determined by hybridization to flow-sorted dot blots derived from a panel of cell lines of chromosome 9 translocations to place probes proximal or distal to each breakpoint. The local map order in 9q32-q34 derived by application of this combination of techniques is as follows: centromere-ALAD- 1.3 Mb-ORM/20 kb/D9S16-GSN-250 kb-C5-HXB-1.9 Mb-D9S21-AK1-1.4 Mb-SPTAN1-ASS-800 kb-ABL-2 Mb-D9S10/350 Kb/DBH-telomere. © 1993 by Academic Press, Inc.

引用

页码：265 / 274

页数：10

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