SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME PYRIMIDINE-2-ONE DERIVATIVES

被引：0

作者：

Yadav, S. S. ^{[1
]}

Yadav, H. N. ^{[1
]}

Yadav, Vijay Kant ^{[1
]}

机构：

[1] Lucknow Inst Technol, Dept Appl Sci & Humanities, Lucknow 226002, Uttar Pradesh, India

来源：

HETEROCYCLIC LETTERS | 2016年 / 6卷 / 01期

关键词：

Pyrimidine; Tetrazole; Chalcones; Antimicrobial Activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrimidine-2-one derivatives (3a-g) were synthesized by reacting the chalcones(1a-g) with urea(2) in presence of potassium hydroxide in ethanol. The chemical structure were confirmed by means of FT-IR, H-1 NMR, mass spectra and elemental analysis. The compounds were screened for antimicrobial activity. The antimicrobial activities are attributed to the presence of 4-NO2, 4-OH and 4-Cl in phenyl ring at 6-position of pyrimidine ring of synthesised compounds. In some cases their activities are equal or more potent than the standard drugs.

引用

页码：71 / 74

页数：4

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