SYNTHESIS AND EVALUATION OF NEW PROTEIN-TYROSINE KINASE INHIBITORS .2. PHENYLHYDRAZONES

被引：17
|
作者：
CUSHMAN, M
NAGARATHNAM, D
GOPAL, D
GEAHLEN, RL
机构：
[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(00)80255-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 33 phenylhydrazone derivatives of polyhydroxylated benzaldehydes has been prepared and tested for inhibition of the protein-tyrosine kinase p56lck. The most potent of these compounds was a competitive inhibitor of p56lck with respect to a tyrosine-containing peptide substrate and was similar in potency to piceatannol, a naturally occurring protein-tyrosine kinase inhibitor.
引用
收藏
页码：215 / 218
页数：4
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