REPAIR OF DNA DAMAGE INDUCED BY REACTIVE OXYGEN SPECIES

被引：66
作者：
BREIMER, LH
机构：
[1] Department of Chemical Pathology and Human Metabolism, Royal Free Hospital School of Medicine, London NW32QG, Pond Street
来源：
FREE RADICAL RESEARCH COMMUNICATIONS | 1991年 / 14卷 / 03期
关键词：
DNA REPAIR; MUTAGENESIS; FREE RADICALS;
D O I：
10.3109/10715769109088945
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA repair limits the mutagenic, and thereby the carcinogenic, effect of DNA modifications. Free radicals, particularly reactive oxygen species, induce all forms of DNA damage, including base modifications, base free sites, strand breakage, and cross-links. These lesions are repaired by a variety of enzymes of partly overlapping substrate specificity, some of which may be induced. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：159 / 171
页数：13
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