INHIBITION OF GROWTH OF HUMAN SMALL-CELL LUNG-CANCER BY BROMOCRIPTINE

被引:0
作者
ISHIBASHI, M
FUJISAWA, M
FURUE, H
MAEDA, Y
FUKAYAMA, M
YAMAJI, T
机构
[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,TOKYO 113,JAPAN
[2] TOKYO METROPOLITAN KOMAGOME HOSP,DEPT PATHOL,TOKYO,JAPAN
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Bromocriptine, a dopaminergic agonist, inhibited the growth of human small cell lung cancer (SCLC) implanted as tumor xenografts in athymic nude mice; the effect was dose dependent. In mice bearing a SCLC with ectopic vasopressin production, plasma levels of human vasopressin associated neurophysin decreased concomitantly. Electron microscopy of tumor tissues revealed marked degenerative changes, including pyknosis, densely aggregated chromatin masses, and vacuolization of cytoplasm after bromocriptine treatment. When a SCLC cell line, NCI-H69, was grown in semisolid medium, bromocriptine inhibited its clonal growth in a dose-related manner. Coincubation with dopamine D-2 receptor antagonist, metoclopramide, or domperidone, completely blocked the inhibitory effect of bromocriptine. Receptor studies with a dopamine D-2 receptor ligand, [I-125]iodosulpride, showed high affinity binding sites on the membranes of SCLC cells. These results indicate that SCLC cells are enriched with dopamine D-2 receptors, which may mediate the growth-inhibitory effect of bromocriptine on SCLC. Dopaminergic agonists may be useful in the medical treatment of SCLC.
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页码:3442 / 3446
页数:5
相关论文
共 31 条
[1]  
ALEXANDER RW, 1988, CANCER RES, V48, P1439
[2]   INHIBITORY-ACTION OF BROMOCRIPTINE AND TAMOXIFEN ON THE GROWTH OF HUMAN PITUITARY-TUMORS IN SOFT AGAR [J].
ARAFAH, BM ;
WILHITE, BL ;
RAINIERI, J ;
BRODKEY, JS ;
PEARSON, OH .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (05) :986-992
[3]   DOPAMINE AGONISTS AND PITUITARY-TUMOR SHRINKAGE [J].
BEVAN, JS ;
WEBSTER, J ;
BURKE, CW ;
SCANLON, MF .
ENDOCRINE REVIEWS, 1992, 13 (02) :220-240
[4]   NEUROPEPTIDE STIMULATION OF CALCIUM FLUX IN HUMAN LUNG-CANCER CELLS - DELINEATION OF ALTERNATIVE PATHWAYS [J].
BUNN, PA ;
DIENHART, DG ;
CHAN, D ;
PUCK, TT ;
TAGAWA, M ;
JEWETT, PB ;
BRAUNSCHWEIGER, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) :2162-2166
[5]   BIOLOGY OF SMALL-CELL LUNG-CANCER [J].
CARNEY, DN .
LANCET, 1992, 339 (8797) :843-846
[6]  
CARNEY DN, 1987, CANCER RES, V47, P821
[7]   BOMBESIN-LIKE PEPTIDES CAN FUNCTION AS AUTOCRINE GROWTH-FACTORS IN HUMAN SMALL-CELL LUNG-CANCER [J].
CUTTITTA, F ;
CARNEY, DN ;
MULSHINE, J ;
MOODY, TW ;
FEDORKO, J ;
FISCHLER, A ;
MINNA, JD .
NATURE, 1985, 316 (6031) :823-826
[8]   DOPAMINE INHIBITS ADENYLATE-CYCLASE IN HUMAN PROLACTIN-SECRETING PITUITARY ADENOMAS [J].
DECAMILLI, P ;
MACCONI, D ;
SPADA, A .
NATURE, 1979, 278 (5701) :252-254
[9]  
ENJALBERT A, 1986, J BIOL CHEM, V261, P4071
[10]   BROMOCRIPTINE INHIBITS PROOPIOMELANOCORTIN MESSENGER-RNA AND ACTH PRECURSOR SECRETION IN SMALL-CELL LUNG-CANCER CELL-LINES [J].
FARRELL, WE ;
CLARK, AJL ;
STEWART, MF ;
CROSBY, SR ;
WHITE, A .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (03) :705-710