GROWTH-FACTORS AND CYTOKINES IN BONE CELL-METABOLISM

被引：118

作者：

CANALIS, E

MCCARTHY, TL

CENTRELLA, M

机构：

[1] ST FRANCIS HOSP,DEPT MED,HARTFORD,CT 06105

[2] UNIV CONNECTICUT,CTR HLTH,FARMINGTON,CT 06032

来源：

ANNUAL REVIEW OF MEDICINE | 1991年 / 42卷

关键词：

BONE FORMATION; BONE MODELING; OSTEOPOROSIS; SKELETAL TISSUE;

D O I：

10.1146/annurev.me.42.020191.000313

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Growth factors regulate the growth and differentiated function of cells. Skeletal cells synthesize fibroblast growth factor, platelet-derived growth factor, insulin-like growth factor, transforming growth factor beta, and additional cytokines. Some of the growth factors produced by bone cells primarily stimulate bone cell replication, whereas others also affect the differentiated function of the osteoblast. Skeletal growth factors also may play a role in the pathogenesis and therapy of metabolic bone disease.

引用

页码：17 / 24

页数：8

共 24 条

[1]

BENTZ H, 1989, J BIOL CHEM, V264, P20805

[2] SOMATOMEDIN (INSULIN-LIKE GROWTH FACTORS)-BINDING PROTEINS - MOLECULAR-FORMS AND REGULATION [J].