Resolution of Multimeric Forms of Circular Plasmids and Chromosomes

被引：23
作者：
Crozat, Estelle [1 ]
Fournes, Florian [1 ]
Cornet, Francois [2 ]
Hallet, Bernard [3 ]
Rousseau, Philippe [1 ]
机构：
[1] Univ Toulouse UPS, Lab Microbiol & Genet Mol, F-31062 Toulouse, France
[2] CNRS, Lab Microbiol & Genet Mol, F-31062 Toulouse, France
[3] UCLouvain, Inst Sci Vie, B-1348 Louvain, Belgium
来源：
MICROBIOLOGY SPECTRUM | 2014年 / 2卷 / 05期
关键词：
D O I：
10.1128/microbiolspec.PLAS-0025-2014
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
One of the disadvantages of circular plasmids and chromosomes is their high sensitivity to rearrangements caused by homologous recombination. Odd numbers of crossing-over occurring during or after replication of a circular replicon result in the formation of a dimeric molecule in which the two copies of the replicon are fused. If they are not converted back to monomers, the dimers of replicons may fail to correctly segregate at the time of cell division. Resolution of multimeric forms of circular plasmids and chromosomes is mediated by site-specific recombination, and the enzymes that catalyze this type of reaction fall into two families of proteins: the serine and tyrosine recombinase families. Here we give an overview of the variety of site-specific resolution systems found on circular plasmids and chromosomes.
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页数：16
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