EFFICACY AND TOXICITY OF DOXORUBICIN CYCLOPHOSPHAMIDE MAINTENANCE THERAPY IN DOGS WITH MULTICENTRIC LYMPHOSARCOMA

被引：76

作者：

PRICE, GS

PAGE, RL

FISCHER, BM

LEVINE, JF

GERIG, TM

机构：

[1] Departments of Microbiology, Pathology and Parasitology, College of Veterinary Medicine

[2] Departments of Statistics, College of Physical and Mathematical Sciences, North Carolina State University

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1991年 / 5卷 / 05期

关键词：

D O I：

10.1111/j.1939-1676.1991.tb03131.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Doxorubicin/cyclophosphamide were evaluated as maintenance drugs for dogs with multicentric lymphosarcoma (n = 28). Median remission time of all dogs was 173 days. Remission duration was shorter, however, in dogs with stage IV/V disease, in dogs with pretreatment hypoalbuminemia, and in dogs that had received glucocorticoids before initiation of chemotherapy (P < 0.04). Nineteen dogs were evaluable for toxicity. Dose-limiting gastrointestinal toxicosis was observed in three dogs, neutropenia was observed in three dogs, and cardiomyopathy was observed in three dogs. The doxorubicin/cyclophosphamide protocol described in this report is safe and effective in treating canine multicentric lymphosarcoma. Clinical stage, pretreatment steroid therapy, and hypoalbuminemia are prognostic factors for response to this protocol.

引用

页码：259 / 262

页数：4

共 17 条

[1]

Postorino NC, Susaneck SJ, Withrow SJ, Et al., Single agent therapy with adriamycin for canine lymphosarcoma, J Am Anim Hosp Assoc, 25, pp. 221-225, (1989)

[2]

Hahn KA, Richardson RC, Bonney PL, Et al., Comparison of two chemotherapy protocols, doxorubicin HCL and COP (Cytoxan, Oncovin and prednisone) in the treatment of canine malignant lymphoma (1980–1986), Vet Cancer Soc Newsl, 12, (1988)

[3]

Carter RF, Harris CK, Withrow SJ, Et al., Chemotherapy of canine lymphoma with histopathological correlation: Doxorubicin alone compared to COP as first treatment regimen, J Am Anim Hosp Assoc, 23, pp. 587-596, (1987)

[4]

Cotter SM, Goldstein MA., Comparison of two protocols for maintenance of remission in dogs with lymphoma, J Am Anim Hosp Assoc, 23, pp. 495-500, (1987)

[5]

MacEwen EG, Hayes AA, Matus RE, Et al., Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog: 147 cases (1978–1981), J Am Vet Med Assoc, 190, pp. 564-568, (1987)

[6]

Gray KN, Raulston GL, Gleiser CA, Et al., Histologic classification as an indication of therapeutic response in malignant lymphoma of dogs, J Am Vet Med Assoc, 184, pp. 814-817, (1984)

[7]

Cotter SM., Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: I. Treatment of Dogs, J Am Anim Hosp Assoc, 19, pp. 159-165, (1983)

[8]

MacEwen EG, Brown NO, Patnaik AK, Et al., Cyclic combination chemotherapy of canine lymphosarcoma, J Am Vet Med Assoc, 178, pp. 1178-1181, (1981)

[9]

Madewell BR., Chemotherapy for canine lymphosarcoma, J Am Vet Med Assoc, 36, pp. 1525-1528, (1975)

[10]

Squire RA, Bush M., Melby EC, Et al., Clinical and pathologic study of canine lymphoma: Clinical staging, cell classification, and therapy, J Natl Cancer Inst, 51, pp. 565-574, (1973)

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