Cytochrome P450 1A1: is it involved in disruption of thyroid hormone action by polychlorinated biphenyl?

被引：0

作者：

Koibuchi, Noriyuki ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Integrat Physiol, Maebashi, Gunma, Japan

来源：

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM | 2011年 / 6卷 / 05期

关键词：

endocrine disruption; environmental chemical; PCB metabolism; thyroid hormone receptor;

D O I：

10.1586/EEM.11.54

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies have shown that the adverse effects of polychlorinated biphenyl (PCB) exposure may be partly induced by disrupting the thyroid hormone system. In the recent article by Giera et al., the effect of specific PCB congeners on the expression of several thyroid hormone-sensitive genes in various organs was studied using developing rats. The addition of PCB126 significantly augmented cytochrome P450 (CYP) 1A1 expression induced by other PCBs. The expression of several genes was also augmented by PCB126, particularly in the liver. These results indicate the involvement of CYP1A1 in PCB-mediated hepatotoxicity. However, this study may not prove directly whether such an effect is exerted though the thyroid hormone system. Further study may be required for clarification.

引用

页码：657 / 659

页数：3

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