KETONE-BODIES ARE SELECTIVELY USED BY INDIVIDUAL BRAIN-REGIONS

被引：157

作者：

HAWKINS, RA ^{[1
]}

BIEBUYCK, JF ^{[1
]}

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT ANESTHESIA,HERSHEY,PA 17033

来源：

SCIENCE | 1979年 / 205卷 / 4403期

关键词：

D O I：

10.1126/science.451608

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Close study of 3-hydroxybutyrate uptake by brain suggests that its metabolism is limited by permeability. Furthermore, the permeability characteristics vary from region to region; areas known to have no blood-brain barrier show the highest rate of utilization. The results imply that rather than substitute fuels, ketone bodies should be considered supplements which partially supply specific areas but are incapable of supporting the entire energy requirement of all brain regions.

引用

页码：325 / 327

页数：3

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