THE RHESUS-MONKEY AS AN ANIMAL-MODEL FOR AGE-RELATED MACULOPATHY

被引：22

作者：

MONACO, WA

WORMINGTON, CM

机构：

[1] St Vincent’s Medical Center, Jacksonville, FL

[2] Pennsylvania College of Optometry, Philadelphia, PA

来源：

OPTOMETRY AND VISION SCIENCE | 1990年 / 67卷 / 07期

关键词：

Drusen; Foveal reflex; Hypopigmentation; Macular degeneration; Pigment mottling; Rhesus monkey;

D O I：

10.1097/00006324-199007000-00011

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In a survey of 100 rhesus monkeys, the prevalence of macular changes was similar to that in age-related macular degeneration in humans. Ophthalmoscopically visible drusen were observed in 31% of the monkeys. A statistically significant correlation existed between the age of the animals and the degree of drusen. Considering equivalent ages, monkeys appear to develop drusen earlier than humans. Pigment mottling occurred in 10% and hypopigmented spots in 8% of the sample. A dull foveal reflex was seen in 8% and no reflex in 27%. There was a statistically significant correlation between the absence of a reflex and the presence of pigment mottling or hypopigmentation in the macula. © 1990 American Academy of Optometry.

引用

页码：532 / 537

页数：6

共 37 条

[1]

Kahn H.A., Moorhead H.B., Statistics on blindness in the model reporting areas 1969-1970. (US Department of Health, Education and Welfare Publication

[2]

(NIH), 73-427, (1973)

[3]

Leibowitz H.M., Krueger D.E., Maunder L.R., Framingham Eye Study. VI. Macular degeneration, Surv Ophthalmol, 24, pp. 428-457, (1980)

[4]

Ferris F., Senile macular degeneration: Review of epidemiologic features, Am J Epidemiol, 118, pp. 132-151, (1983)

[5]

Ferris F., Fine S.L., Hyman L.A., Age-related macular degeneration and blindness due to neovascular maculopathy, Arch Ophthalmol, 102, pp. 1640-1642, (1984)

[6]

Gass J., Pathogenesis of disciform detachment of the neuroepithelium. I. General concepts and classification, Am J Ophthalmol, 63, pp. 573-585, (1967)

[7]

Friedman A.H., Pokorny K.S., Suhan J.P., Kornzwelg A.L., Senile macular degeneration: Clinical hlstopathological and ultra-structural studies, Mt Sinai J Med NY, 47, pp. 227-245, (1980)

[8]

Young R.W., Pathophysiology of age-related macular degeneration, Surv Ophthalmol, 31, pp. 291-306, (1987)

[9]

Kahn H.A., Leibowltz H.M., Ganley J.P., Kinl M.M., Colton T., Nickerson R.S., Dawber T.R., The Framingham Eye Study. II. Association of ophthalmic pathology with single variables previously measured In the Framingham Heart Study, Am J Epidemiol, 106, pp. 33-41, (1977)

[10]

Hyman L.G., Lilienfeld A.M., Ferris F., Fine S.L., Senile macular degeneration: A case-control study, Am J Epidemiol, 118, pp. 213-227, (1983)

← 1 2 3 4 →