EFFECTS OF INTRAAMYGDALOID INJECTION OF TAURINE AND VALYLTAURINE ON AMYGDALOID KINDLED SEIZURE IN RATS

被引：0

作者：

UEMURA, S ^{[1
]}

IENAGA, K ^{[1
]}

HIGASHIURA, K ^{[1
]}

KIMURA, H ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,INST MOLEC NEUROBIOL,DIV NEUROANAT,TSUKINOWACHO,OTSU,SHIGA 52021,JAPAN

来源：

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY | 1991年 / 45卷 / 02期

关键词：

AMYGDALOID KINDLING; ANTICONVULSANT; TAURINE; VALYTAURINE;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antiepileptic effects of intracerebral injections of taurine and valyltaurine were examined in amygdaloid kindled rats. The effects were assessed whether the animals can evoke generalized seizures by a 10-mu-A higher stimulation intensity than triggering thresholds. In all fully-kindled animals that have received intraamygdaloid injection of 500 nmol taurine, the kindled seizure was completely abolished. Such a significant seizure suppression (p < 0.05) was observed 12-24 h after the taurine injection. Valyltaurine (500 nmol) also suppressed the seizure in 60% of animals tested, but the effect was not statistically significant. The results indicate that taurine may effectively suppress epileptic seizures when it acts directly at the stimulation site amygdala.

引用

页码：383 / 385

页数：3

共 4 条

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[3] IMMUNOHISTOCHEMICAL AND BIOCHEMICAL-STUDIES OF SUBSTANCES WITH TAURINE-LIKE IMMUNOREACTIVITY IN THE BRAIN
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[J]. ACTA HISTOCHEMICA ET CYTOCHEMICA, 1987, 20 (01) : 31 - 40
[4] EFFECTS OF TAURINE ON KINDLED AMYGDALOID SEIZURES IN RATS, CATS, AND PHOTOSENSITIVE BABOONS
WADA, JA
OSAWA, T
WAKE, A
CORCORAN, ME
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