DELAYED NEUROTOXICITY OF PHENYLPHOSPHONOTHIOATE ESTERS

被引：40
作者：
ABOUDONIA, MB
机构：
[1] Department of Pharmacology, Duke University Medical Center, Durham
来源：
SCIENCE | 1979年 / 205卷 / 4407期
关键词：
D O I：
10.1126/science.462181
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.
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页码：713 / 715
页数：3
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