ANTIMALARIAL-DRUGS - IS THE LYSOSOMOTROPIC HYPOTHESIS STILL VALID

被引：24
作者：
GINSBURG, H
机构：
[1] Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem
来源：
PARASITOLOGY TODAY | 1990年 / 6卷 / 10期
关键词：
D O I：
10.1016/0169-4758(90)90178-7
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Although quinine and its congener chloroquine have been used as antimalarials for many years, and their analog, mefloquine, has been recently introduced, the precise mode of action of these quinoline-containing drugs is not fully understood. The lysosomotropic hypothesis is favoured1,2 and Hagai Ginsburg here discusses its principles and its reliability in view of both the physicochemical character of the drugs and new experimental evidence. © 1990.
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页码：334 / 337
页数：4
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