TGF-beta Regulates Production of Growth Factors and TGF-beta by Human Peripheral Blood Monocytes

被引：174

作者：

McCartney-Francis, Nancy ^{[1
]}

Mizel, Diane ^{[1
]}

Wong, Henry ^{[1
]}

Wahl, Larry ^{[1
]}

Wahl, Sharon ^{[1
]}

机构：

[1] NIDR, Cellular Immunol Sect, Lab Immunol, NIH, Bethesda, MD 20892 USA

来源：

GROWTH FACTORS | 1990年 / 4卷 / 01期

关键词：

TGF-beta; monocyte; cytokine;

D O I：

10.3109/08977199009011007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor beta 1 (TGF-beta 1) and its closely related homologue, TGF-beta 2, rapidly induce growth factor gene expression by freshly isolated human peripheral blood monocytes. Within 3 h of exposure to TGF-beta, mRNA species specific for interleukin-1 (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) were observed. By 14-18 h, cytokine bioactivity and protein were detected in the culture supernatants. Furthermore, not only TGF-beta 1, but also TGF-beta 2. mRNA are expressed constitutively in unstimulated monocytes. However, in response to exogenous TGF-beta (beta 1 or beta 2), only TGF-beta 1 gene expression is upregulated, and the expression of TGF-beta 2 mRNA is unchanged. This selective autoinduction of TGF-beta 1 appears to be controlled at both transcriptional and post-transcriptional levels. These paracrine and autocrine activities of TGF-beta suggest potential mechanisms through which an inflammatory response can be initiated and amplified. In addition, the TGF-beta enhancement of growth factor generation may promote fibrosis and angiogenesis relevant to physiological tissue repair as well as pathological fibrotic sequelae.

引用

页码：27 / 35

页数：10

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