EFFECTS OF FATTY-ACIDS AND FATTY ACYL COA ESTERS ON CU2+-INDUCED CONVERSION OF XANTHINE DEHYDROGENASE TO OXIDASE IN RABBIT LIVER

被引：6

作者：

FUJITA, T ^{[1
]}

SAKUMA, S ^{[1
]}

FUJIMOTO, K ^{[1
]}

YOSHIOKA, K ^{[1
]}

ASHIDA, E ^{[1
]}

NISHIDA, H ^{[1
]}

FUJIMOTO, Y ^{[1
]}

机构：

[1] OSAKA UNIV PHARMACEUT SCI,DEPT HYG CHEM,MATSUBARA,OSAKA 580,JAPAN

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1995年 / 19卷 / 04期

关键词：

XANTHINE OXIDASE; XANTHINE DEHYDROGENASE; FATTY ACIDS; FATTY ACYL COA ESTERS; RABBIT LIVER; FREE RADICALS;

D O I：

10.1016/0891-5849(95)00029-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of various fatty acids and fatty acyl CoA esters on Cu2+-induced conversion of xanthine dehydrogenase to oxidase in rabbit liver were examined. Cu2+ (2-10 mu M) brought about the conversion of xanthine dehydrogenase to oxidase in a dose-dependent manner. Oleic, arachidonic, eicosapentaenoic, and docosahexaenoic acids (50-200 mu M) prevented the conversion of xanthine dehydrogenase to oxidase catalyzed by 6 mu M-Cu2+. The effect of these four fatty acids was concentration-dependent, whereas palmitic, stearic, and linoleic acids had no effect on the conversion of xanthine dehydrogenase to oxidase at the same concentration range. On the other hand, palmitoyl, linoleoyl, and arachidonoyl CoAs elicited the inhibition of 6 mu M-Cu2+-induced conversion of xanthine dehydrogenase to oxidase at concentrations of 50, 100, and 200 mu M. These results suggest that oleic, arachidonic, eicosapentaenoic and docosahexaenoic acids, and fatty acyl CoAs have the potential to inhibit the conversion of xanthine dehydrogenase to oxidase in rabbit liver.

引用

页码：487 / 491

页数：5

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