STRIATAL SUBREGIONS ARE DIFFERENTIALLY VULNERABLE TO THE NEUROTOXIC EFFECTS OF METHAMPHETAMINE

被引：102

作者：

EISCH, AJ ^{[1
]}

GAFFNEY, M ^{[1
]}

WEIHMULLER, FB ^{[1
]}

ODELL, SJ ^{[1
]}

MARSHALL, JF ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT PSYCHOBIOL, IRVINE, CA 92717 USA

来源：

BRAIN RESEARCH | 1992年 / 598卷 / 1-2期

关键词：

METHAMPHETAMINE; STRIATUM; NEUROTOXICITY; HETEROGENEITY; DOPAMINE; MAZINDOL; AUTORADIOGRAPHY; RAT;

D O I：

10.1016/0006-8993(92)90201-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [H-3]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogeneous. The ventral caudate-putamen displayed the greatest decrease in both [H-3]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.

引用

页码：321 / 326

页数：6

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