A SIMULATION STUDY ON A SELF-TUNING PORTABLE CONTROLLER OF BLOOD-GLUCOSE

被引:17
作者
BRUNETTI, P
COBELLI, C
CRUCIANI, P
FABIETTI, PG
FILIPPUCCI, F
SANTEUSANIO, F
SARTI, E
机构
[1] UNIV PERUGIA,INST MED PATHOL,BIOENGN LAB,I-06100 PERUGIA,ITALY
[2] UNIV PADUA,DEPT ELECTR & COMP SCI,I-35100 PADUA,ITALY
[3] UNIV BOLOGNA,DEPT ELECTR COMP & SYST SCI,I-40126 BOLOGNA,ITALY
关键词
DIABETES; WEARABLE ARTIFICIAL PANCREAS; SELF-TUNING CONTROLLER; COMPUTER SIMULATION;
D O I
10.1177/039139889301600111
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A self-tuning, nonlinear controller was developed to drive portable or implantable micro-pumps for blood glucose control in diabetic subjects. The parameter estimation is based on a recursive least-square algorithm applied to a discrete time simplified mathematical model of the glucose system; the controller, which is integrated with the estimator, uses an extended minimum-variance method. The software was designed to drive a micro-controller wearable unit, operating with different kinds of glucose sensors, in order to perform chemical and biological experimentations. Some strategies were introduced to avoid hypoglycaemia, even tolerating a reduction in control speed and accuracy. The whole system was tested in a simulation study, performed on a mathematical model implemented on a personal computer. The tests were performed while simulating different controller structures and settings, and patient responses. They showed a satisfactory control behaviour, mostly as far as stability and robustness are concerned, in all simulated conditions.
引用
收藏
页码:51 / 57
页数:7
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