INTERFERON-GAMMA INTERRUPTS AUTOCRINE GROWTH MEDIATED BY ENDOGENOUS INTERLEUKIN-6 IN RENAL-CELL CARCINOMA

被引：23

作者：

GRUSS, HJ ^{[1
]}

BRACH, MA ^{[1
]}

MERTELSMANN, RH ^{[1
]}

HERRMANN, F ^{[1
]}

机构：

[1] UNIV FREIBURG,MED CTR,DEPT INTERNAL MED 1,HUGSTETTER STR 55,W-7800 FREIBURG,GERMANY

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 49卷 / 05期

关键词：

D O I：

10.1002/ijc.2910490523

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells of the renal-cell carcinoma line ACHN constitutively produce IL-6, express the IL-6 receptor and use IL-6 in n autocrine fashion to augment their growth. Growth arrest of ACHN cells can be achieved by exposure of cells to neutralizing monoclonal antibody (MAb) to recombinant human (rh) IL-6. Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of Proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (H-3-thymidine uptake) of ACHN cells and IL-6 expression. Studies on the mechanism of action of IFN-gamma revealed that IFN-gamma was acting by inhibiting the autocrine IL-6-mediated loop generated by ACHN.

引用

页码：770 / 773

页数：4

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