EFFECTS OF OFLOXACIN ON CELL-MEDIATED IMMUNE-RESPONSE AND LYMPHOKINE PRODUCTION

被引：2

作者：

BIGLINO, A ^{[1
]}

FORNO, B ^{[1
]}

POLLONO, AM ^{[1
]}

BUSSO, M ^{[1
]}

ARPINELLI, F ^{[1
]}

BENEDETTI, M ^{[1
]}

PUGLIESE, A ^{[1
]}

机构：

[1] GLAXO PRODOTTI FARMACEUT SPA,I-37100 VERONA,ITALY

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1990年 / 25卷 / 05期

关键词：

D O I：

10.1093/jac/25.5.797

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The effects of orally administered ofloxacin on functional parameters of cell-mediated immunity were investigated in 15 patients with respiratory or urinary tract infections. Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of γ-interferon, interleulrin-2 and α-interferon. An increase in proliferative response to pokeweed mitogen and a slight but significant decrease in α-interferon production were observed, while other parameters remained unaffected by treatment. © 1990 The British Society for Antimicrobial Chemotherapy.

引用

页码：797 / 802

页数：6

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