CONTINUOUS MONITORING OF UNBOUND FLOMOXEF LEVELS IN RAT-BLOOD USING MICRODIALYSIS AND ITS NEW PHARMACOKINETIC ANALYSIS

被引：0
作者：
SAISHO, Y
UMEDA, T
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 03期
关键词：
MICRODIALYSIS; FLOMOXEF; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAFILTRATION; PHARMACOKINETIC PARAMETER;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microdialysis sampling method coupled to high-performance liquid chromatography with UV detection was applied to continuous monitoring of in vivo unbound flomoxef concentration in rat blood. By comparsion with ultrafiltration method, it was demonstrated that it gave reliable results for the unbound drug monitoring in blood. Furthermore, a new method was presented for the calculation of pharmacokinetic parameters from the data obtained by the microdialysis method.
引用
收藏
页码：808 / 810
页数：3
相关论文
共 9 条
1