SEROTONIN, MEMORY, AND THE AGING BRAIN

被引：241

作者：

MCENTEE, WJ ^{[1
]}

CROOK, TH ^{[1
]}

机构：

[1] MEMORY ASSESSMENT CLIN INC,BETHESDA,MD 20814

来源：

PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期

关键词：

SEROTONIN; MONOAMINES; MEMORY; AGING;

D O I：

10.1007/BF02244194

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin is widely distributed throughout the central nervous system and is implicated in a variety of neural functions such as pain, feeding, sleep, sexual behavior, cardiac regulation and cognition. This paper is concerned with the last of these. Abnormalities of the serotonergic nervous system are well documented in pathologic studies of Alzheimer's disease and there is evidence suggesting that changes in this system occur in association with non-disease aging. Data on the role of serotonin in learning and memory and on the effects of aging on brain serotonin function are reviewed and discussed in relation to pharmacologic treatment strategies for the memory impairments associated with advancing age.

引用

页码：143 / 149

页数：7

共 85 条

[1] BIOCHEMICAL-EVIDENCE OF SELECTIVE NERVE-CELL CHANGES IN THE NORMAL AGING HUMAN AND RAT-BRAIN [J].