ATROPHY OF CHOLINERGIC NEURONS WITHIN THE RAT NUCLEUS BASALIS MAGNOCELLULARIS FOLLOWING INTRACORTICAL AF64A INFUSION

被引：6

作者：

MOUTON, PR

ARENDASH, GW

机构：

[1] UNIV S FLORIDA, DEPT BIOL, TAMPA, FL 33620 USA

[2] UNIV S FLORIDA, DEPT NEUROL, TAMPA, FL 33620 USA

来源：

NEUROSCIENCE LETTERS | 1990年 / 111卷 / 1-2期

关键词：

Acetylcholinesterase; Atrophy; Cholinergic neuron; Cholinotoxicity; High-affinity choline transport; Intracortical AF64A; Nucleus basalis;

D O I：

10.1016/0304-3940(90)90343-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The rat nucleus basalis magnocellularis (nBM) was morphometrically analyzed following multiple intracortical AF64A infusions. At 3 weeks post-infusion, brains were histochemically double-stained for acetylcholinesterase and Nissl substance following diisopropylfluorophosphate pretreatment. Intracortical AF64A induced significant atrophy, but not degeneration, of nucleus basalis cholinergic cell bodies. These results suggest that retrograde cellular atrophy is associated with inhibition of presynaptic high-affinity choline transport on cortical terminals of nBM cholinergic neurons. © 1990.

引用

页码：52 / 57

页数：6

共 25 条

[1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].