PREPARATION AND CHARACTERIZATION OF ETHYLCELLULOSE-WALLED THEOPHYLLINE MICROCAPSULES USING THE EMULSION-SOLVENT EVAPORATION TECHNIQUE

被引：5

作者：

AMPERIADOU, A ^{[1
]}

GEORGARAKIS, M ^{[1
]}

机构：

[1] ARISTOTELIAN UNIV THESSALONIKI,DEPT PHARM,PHARMACEUT & DRUG CONTROL SECT,GR-54006 THESSALONIKI,GREECE

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 11期

关键词：

D O I：

10.3109/03639049509063022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ethylcellulose microcapsules containing theophylline are prepared by emulsification of a organic ethylcellulose solution in a oil phase containing a surfactant. The preparation is based on dispersion of acetone containing the drug in liquid paraffin. Tween 80 was used as a dispersing agent. Good reproducibility in microcapsule preparation was observed. The microcapsules obtained were uniform and free-flowing particles. The type of the stirring-manner (propella - and magnet - stirring), and the drug to polymer ratios have an important influence on the in vitro dissolution and release of theophylline from microcapsules.

引用

页码：1339 / 1346

页数：8

共 12 条

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[2]

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[3]

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[4]

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