POLYMORPHISM AND PERIPHERAL LEVELS OF APOLIPOPROTEIN(A) IN POLYGENIC HYPERCHOLESTEROLEMIA AND COMBINED HYPERLIPIDEMIA

被引：0
|
作者：
SHEN, GX [1 ]
MYMIN, D [1 ]
DEMBINSKI, T [1 ]
KRAHN, A [1 ]
ANGEL, A [1 ]
机构：
[1] UNIV MANITOBA,DEPT CLIN CHEM,WINNIPEG,MB R3E 3J7,CANADA
来源：
CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE | 1995年 / 18卷 / 01期
关键词：
APOLIPOPROTEIN(A); POLYGENIC HYPERCHOLESTEROLEMIA; COMBINED HYPERLIPIDEMIA;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This study demonstrates that peripheral apolipoprotein(a) [apo(a)] levels are higher in patients with polygenic hypercholesterolemia (PH) and combined hyperlipidemia (CH) than in controls. Levels of apo(a) inversely correlate with apo(a) isoform sizes. For a given apo(a) isoform, apo(a) levels are higher in PH and CH patients. Higher frequencies of smaller apo(a) isoforms were found in PH and CH patients than in controls, and in patients with coronary artery disease (CAD) or a family history of premature cardiovascular diseases than in patients without CAD or family history.
引用
收藏
页码：33 / 41
页数：9
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