TRILINOLEIN INHIBITS EPINEPHRINE-INDUCED HUMAN PLATELET-AGGREGATION

被引：10

作者：

LAI, LJ

SHEN, YC

HONG, CY

机构：

[1] NATL YANG MING MED COLL,INST TRADIT MED,TAIPEI,TAIWAN

[2] VET GEN HOSP,DEPT MED,TAIPEI,TAIWAN

来源：

THROMBOSIS RESEARCH | 1994年 / 76卷 / 03期

关键词：

PLATELET AGGREGATION; EPINEPHRINE; TRIGLYCERIDE; TRILINOLEIN; THROMBOXANE;

D O I：

10.1016/0049-3848(94)90199-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

At concentrations ranging from 10(-9) to 10(-6) M, trilinolein inhibited epinephrine-induced platelet aggregation. This inhibition was accompanied by reduced ATP release and thromboxane B-2 formation. However, concentration-response curves for the interaction between trilinolein and epinephrine showed that trilinolein was unlikely a competitive antagonist of epinephrine. Platelet aggregation induced by collagen, thrombin, ADP or arachidonic acid was not inhibited. This study supported the theory that this type of triglyceride may have therapeutic potential but the definite mechanism for its effect remains to be answered.

引用

页码：281 / 287

页数：7

共 14 条

[1]

BENNETTJ, 1992, DISEASE MONTH, V38, P581

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