EVIDENCE FOR RETROGRADE AXONAL-TRANSPORT OF MPP+ IN THE RAT

被引：18

作者：

CAMPBELL, KJ ^{[1
]}

TAKADA, M ^{[1
]}

HATTORI, T ^{[1
]}

机构：

[1] UNIV TENNESSEE,CTR HLTH SCI,DEPT ANAT & NEUROBIOL,MEMPHIS,TN 38163

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 02期

关键词：

Dorsal raphe; MPP[!sup]+[!/sup; MPTP; Rat; Retrograde transport; Striatum; Substantia nigra;

D O I：

10.1016/0304-3940(90)90614-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Three to 24h after injecting radioactive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ([3H]MPTP) into the rat striatum, a considerable number of neuronal perikarya were retrogradely radiolabeled in the dorsal raphe, substantia nigra pars compacta and selected regions of the substantia nigra pars reticulata, leaving cells in the ventral tegmental area unlabeled. Pretreatment with tranylcypromine prevented such radiolabel accumulation, indicating that 1-methyl-4-phenylpyridine (MPP+) (but not MPTP) undergoes selective uptake and subsequent retrograde transport in these specific striatal afferent systems. © 1990.

引用

页码：151 / 154

页数：4

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