HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION OF BUPRENORPHINE AND ITS MAJOR METABOLITE IN URINE

被引：27

作者：

DEBRABANDERE, L ^{[1
]}

VANBOVEN, M ^{[1
]}

DAENENS, P ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,DEPT TOXICOL,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 564卷 / 02期

关键词：

D O I：

10.1016/0378-4347(91)80524-G

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A procedure was developed for the simultaneous determination of buprenorphine and its major metabolite, N-desalkylbuprenorphine, by reversed-phase high-performance liquid chromatography with electrochemical detection. The detection limit is about 100 pg/ml for the major metabolite and 250 pg/ml for buprenorphine.

引用

页码：557 / 566

页数：10