HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION OF BUPRENORPHINE AND ITS MAJOR METABOLITE IN URINE

被引：27
作者：
DEBRABANDERE, L [1 ]
VANBOVEN, M [1 ]
DAENENS, P [1 ]
机构：
[1] CATHOLIC UNIV LEUVEN,DEPT TOXICOL,B-3000 LOUVAIN,BELGIUM
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 564卷 / 02期
关键词：
D O I：
10.1016/0378-4347(91)80524-G
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A procedure was developed for the simultaneous determination of buprenorphine and its major metabolite, N-desalkylbuprenorphine, by reversed-phase high-performance liquid chromatography with electrochemical detection. The detection limit is about 100 pg/ml for the major metabolite and 250 pg/ml for buprenorphine.
引用
收藏
页码：557 / 566
页数：10
相关论文
共 22 条
  • [1] THE RADIOIMMUNOASSAY OF BUPRENORPHINE
    BARTLETT, AJ
    LLOYDJONES, JG
    RANCE, MJ
    FLOCKHART, IR
    DOCKRAY, GJ
    BENNETT, MRD
    MOORE, RA
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 18 (04) : 339 - 345
  • [2] ANALYSIS OF BUPRENORPHINE AND ITS N-DEALKYLATED METABOLITE IN PLASMA AND URINE BY SELECTED-ION MONITORING
    BLOM, Y
    BONDESSON, U
    ANGGARD, E
    [J]. JOURNAL OF CHROMATOGRAPHY, 1985, 338 (01): : 89 - 98
  • [3] SUB-LINGUAL BUPRENORPHINE USED POSTOPERATIVELY - 10-HOUR PLASMA DRUG CONCENTRATION ANALYSIS
    BULLINGHAM, RES
    MCQUAY, HJ
    PORTER, EJB
    ALLEN, MC
    MOORE, RA
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 13 (05) : 665 - 673
  • [4] BUPRENORPHINE KINETICS
    BULLINGHAM, RES
    MCQUAY, HJ
    MOORE, A
    BENNETT, MRD
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 28 (05) : 667 - 672
  • [5] CLINICAL PHARMACOKINETICS OF NARCOTIC AGONIST-ANTAGONIST DRUGS
    BULLINGHAM, RES
    MCQUAY, HJ
    MOORE, RA
    [J]. CLINICAL PHARMACOKINETICS, 1983, 8 (04) : 332 - 343
  • [6] ELECTRON-CAPTURE GAS-CHROMATOGRAPHIC ASSAY FOR BUPRENORPHINE AND METABOLITES IN HUMAN-URINE AND FECES
    CONE, EJ
    GORODETZKY, CW
    YOUSEFNEJAD, D
    DARWIN, WD
    [J]. JOURNAL OF CHROMATOGRAPHY, 1985, 337 (02): : 291 - 300
  • [7] CONE EJ, 1985, DRUG METAB DISPOS, V12, P577
  • [8] DIRIX A, 1988, OLYMPIC BOOK SPORTS, V1, P669
  • [9] Engel J., 1987, PHARM WIRKSTOFFE
  • [10] SENSITIVE SCREENING METHOD FOR BUPRENORPHINE IN URINE
    HACKETT, LP
    DUSCI, LJ
    ILETT, KF
    SEOW, SSW
    QUIGLEY, AJ
    [J]. JOURNAL OF CHROMATOGRAPHY, 1986, 374 (02): : 400 - 404
123