LIPID PEROXIDES, GLUTATHIONE-PEROXIDASE, HIGH-DENSITY-LIPOPROTEIN SUBFRACTIONS AND APOLIPOPROTEINS IN YOUNG-ADULTS

被引：18

作者：

LUOMA, PV

STENGARD, J

KORPELA, H

RAUTIO, A

SOTANIEMI, EA

SUVANTO, E

MARNIEMI, J

机构：

[1] DEACONESS INST OULU,OULU,FINLAND

[2] SOCIAL INSURANCE INST,REHABIL RES CTR,TURKU,FINLAND

来源：

JOURNAL OF INTERNAL MEDICINE | 1990年 / 227卷 / 04期

关键词：

apolipoprotein A‐I; A‐II; B; cholesterol; glutathione peroxidase; HDL[!sub]2[!/sub]/HDL[!sub]3[!/sub; lipid peroxide;

D O I：

10.1111/j.1365-2796.1990.tb00161.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. Lipid peroxides have been implicated in the initiation of atherogenesis. In this study of 23 young healthy subjects, high levels of serum lipid peroxides were associated with low serum HDL2 cholesterol concentrations and low HDL2/HDL3 cholesterol and apolipo‐protein A‐I/A‐II ratios. Low levels of LDL cholesterol and apolipoprotein B, and low apolipoprotein B/A‐I ratios were typical of subjects with high serum glutathione peroxidase activities. Serum lipid peroxide levels varied widely in subjects without abnormal cholesterol, HDL cholesterol or LDL cholesterol concentrations. This variation may play a role in the frequent occurrence of coronary artery disease in normolipidaemic individuals. 1990 Blackwell Publishing Ltd

引用

页码：287 / 289

页数：3

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