EFFECT OF INOCULUM SIZE ON ANTIMICROBIAL SUSCEPTIBILITY OF HELICOBACTER-PYLORI

被引：8

作者：

BERGER, SA

GOREA, A

MOSKOWITZ, M

SANTO, M

GILAT, T

机构：

[1] ICHILOV HOSP,ELIAS SOURASKY MED CTR,DEPT GASTROENTEROL,IL-64239 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1993年 / 12卷 / 10期

关键词：

D O I：

10.1007/BF02098470

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An agar dilution assay was used to assess the effect of inoculum size and culture period on the susceptibility of 15 clinical isolates of Helicobacter pylori to ampicillin, erythromycin, tetracycline, chloramphenicol, metronidazole and tinidazole. The mean MIC of the isolates increased 2.2- to 21.2-fold as the inoculum size progressed from 10(3) to 10(7) cfu/spot. Identical results were noted when isolates were maintained for two or four days prior to testing. Inoculum size should be carefully controlled when assessing the in vitro susceptibility of Helicobacter pylori.

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页码：782 / 783

页数：2

相关论文

共 12 条

[1]

Barry A. L., 1986, ANTIBIOTICS LABORATO, P1

[2] CAMPYLOBACTER-PYLORI ISOLATED FROM THE STOMACH OF THE MONKEY, MACACA-NEMESTRINA [J].

BRONSDON, MA ;

SCHOENKNECHT, FD .

JOURNAL OF CLINICAL MICROBIOLOGY, 1988, 26 (09) :1725-1728

[3] RELATION OF CAMPYLOBACTER-PYLORIDIS TO GASTRITIS AND PEPTIC-ULCER [J].

BUCK, GE ;

GOURLEY, WK ;

LEE, WK ;

SUBRAMANYAM, K ;

LATIMER, JM ;

DINUZZO, AR .

JOURNAL OF INFECTIOUS DISEASES, 1986, 153 (04) :664-669

[4] EVALUATION OF THE BACTERICIDAL ACTIVITY OF BETA-LACTAM ANTIBIOTICS ON SLOWLY GROWING BACTERIA CULTURED IN THE CHEMOSTAT [J].

COZENS, RM ;

TUOMANEN, E ;

TOSCH, W ;

ZAK, O ;

SUTER, J ;

TOMASZ, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (05) :797-802

[5] EVALUATION OF THE E-TEST FOR QUANTITATIVE ANTIMICROBIAL SUSCEPTIBILITY TESTING OF HELICOBACTER-PYLORI [J].

GLUPCZYNSKI, Y ;

LABBE, M ;

HANSEN, W ;

CROKAERT, F ;

YOURASSOWSKY, E .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (09) :2072-2075

[6] METRONIDAZOLE RESISTANCE IN HELICOBACTER-PYLORI [J].

GLUPCZYNSKI, Y ;

BURETTE, A ;

DEKOSTER, E ;

NYST, JF ;

DELTENRE, M ;

CADRANEL, S ;

BOURDEAUX, L ;

DEVOS, D .

LANCET, 1990, 335 (8695) :976-977

[7] THE MINIMUM INHIBITORY AND BACTERICIDAL CONCENTRATIONS OF ANTIBIOTICS AND ANTIULCER AGENTS AGAINST CAMPYLOBACTER-PYLORIDIS [J].

GOODWIN, CS ;

BLAKE, P ;

BLINCOW, E .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 17 (03) :309-314

[8] SUSCEPTIBILITY OF CAMPYLOBACTER-PYLORIDIS TO 20 ANTIMICROBIAL AGENTS [J].

LAMBERT, T ;

MEGRAUD, F ;

GERBAUD, G ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (03) :510-511

[9] ATTEMPT TO FULFILL KOCH POSTULATES FOR PYLORIC CAMPYLOBACTER [J].

MARSHALL, BJ ;

ARMSTRONG, JA ;

MCGECHIE, DB ;

GLANCY, RJ .

MEDICAL JOURNAL OF AUSTRALIA, 1985, 142 (08) :436-439

[10]

MCNULTY CAM, 1988, EUR J CLIN MICROBIOL, V7, P565