THE EFFECT OF TROPISETRON INJECTED INTO THE NUCLEUS-ACCUMBENS-SEPTI ON ETHANOL-CONSUMPTION IN RATS

被引：12

作者：

JANKOWSKA, E ^{[1
]}

KOSTOWSKI, W ^{[1
]}

机构：

[1] INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,PL-02957 WARSAW,POLAND

来源：

ALCOHOL | 1995年 / 12卷 / 03期

关键词：

ETHANOL INTAKE; ETHANOL PREFERENCE; 5-HT3; RECEPTOR; ANTAGONIST; ICS; 205-930; TROPISETRON; NUCLEUS ACCUMBENS SEPTI; RAT;

D O I：

10.1016/0741-8329(94)00082-O

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Earlier studies have shown that 5-HT3 antagonists possess properties of reducing ethanol (EtOH) preference and intake in EtOH high-preferring rats. In this study we examined the effect of tropisetron (ICS 205-930) microinjection (1 and 10 ng) into the nucleus accumbens septi (NAS) on EtOH drinking in a scheduled access to EtOH paradigm. Control rats received vehicle only. Tropisetron, when injected bilaterally into the NAS, significantly reduced EtOH intake in EtOH high-preferring animals. It is concluded that 5-HT3 antagonists might exert their antipreference activity by influencing the receptors within the NAS and that 5-HT3 receptors might play an important role in reinforcing properties of EtOH.

引用

页码：195 / 198

页数：4

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