REVERSIBLE LYMPHOMAS ASSOCIATED WITH EPSTEIN-BARR-VIRUS OCCURRING DURING METHOTREXATE THERAPY FOR RHEUMATOID-ARTHRITIS AND DERMATOMYOSITIS

被引:372
作者
KAMEL, OW
VANDERIJN, M
WEISS, LM
DELZOPPO, GJ
HENCH, PK
ROBBINS, BA
MONTGOMERY, PG
WARNKE, RA
DORFMAN, RF
机构
[1] CITY HOPE NATL MED CTR, DEPT PATHOL, DUARTE, CA 91010 USA
[2] SCRIPPS RES INST, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
[3] SCRIPPS CLIN, DIV HEMATOL MED ONCOL, LA JOLLA, CA 92037 USA
[4] SCRIPPS CLIN, DIV RHEUMATOL, LA JOLLA, CA 92037 USA
[5] SCRIPPS CLIN, DEPT PATHOL, LA JOLLA, CA 92037 USA
[6] MTN STATES TUMOR INST, DIV HEMATOL ONCOL, BOISE, ID USA
关键词
D O I
10.1056/NEJM199305063281806
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An increased risk of lymphoproliferative disorders has been well documented in patients who are treated with immunosuppressive agents after organ transplantation1 and in patients with the acquired immunodeficiency syndrome2. The lymphomas that develop in immunosuppressed patients after transplantation are typically large-cell lymphomas that contain Epstein-Barr virus (EBV) and are closely linked to the level of competence of the immune system3. When treatment with immunosuppressive drugs is reduced or discontinued, these EBV-associated lymphomas may regress completely1; if the patient's immune status continues to be compromised, however, the tumor may continue to proliferate and result in death. Whether patients… © 1993, Massachusetts Medical Society. All rights reserved.
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收藏
页码:1317 / 1321
页数:5
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