CHROMOSOMAL LOCALIZATION OF GLUTAMATE RECEPTOR GENES - RELATIONSHIP TO FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS AND OTHER NEUROLOGICAL DISORDERS OF MICE AND HUMANS

被引：59
作者：
GREGOR, P
REEVES, RH
JABS, EW
YANG, XD
DACKOWSKI, W
ROCHELLE, JM
BROWN, RH
HAINES, JL
OHARA, BF
UHL, GR
SELDIN, MF
机构：
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PHYSIOL, BALTIMORE, MD 21205 USA
[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PEDIAT & MED, BALTIMORE, MD 21205 USA
[3] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL & NEUROSCI, BALTIMORE, MD 21205 USA
[4] INTEGRATED GENET INC, FRAMINGHAM, MA 01701 USA
[5] DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA
[6] DUKE UNIV, MED CTR, DEPT MICROBIOL, DURHAM, NC 27710 USA
[7] MASSACHUSETTS GEN HOSP, DAY NEUROMUSCULAR RES CTR, BOSTON, MA 02129 USA
[8] MASSACHUSETTS GEN HOSP, MOLEC NEUROGENET UNIT, BOSTON, MA 02129 USA
[9] STANFORD UNIV, DEPT BIOL SCI, STANFORD, CA 94305 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 07期
关键词：
D O I：
10.1073/pnas.90.7.3053
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Receptors for the major excitatory neurotransmitter glutamate may play key roles in neurodegeneration. The mouse Glur-5 gene maps to chromosome 16 between App and Sod-1. The homologous human GLUR5 gene maps to the corresponding region of human chromosome 21, which contains the locus for familial amyotrophic lateral sclerosis. This location, and other features, render GLUR5 a possible candidate gene for familial amyotrophic lateral sclerosis. In addition, dosage imbalance of GLUR5 may have a role in the trisomy 21 (Down syndrome). Further characterization of the murine glutamate receptor family includes mapping of Glur-1 to the same region as neurological mutants spasmodic, shaker-2, tipsy, and vibrator on chromosome 11; Glur-2 near spastic on chromosome 3; Glur-6 near waltzer and Jackson circler on chromosome 10; and Glur-7 near clasper on chromosome 4.
引用
收藏
页码：3053 / 3057
页数：5
相关论文
共 76 条
[1]   MAPPING OF THE MOUSE X-CHROMOSOME USING RANDOM GENOMIC PROBES AND AN INTERSPECIFIC MOUSE CROSS [J].
AMAR, LC ;
ARNAUD, D ;
CAMBROU, J ;
GUENET, JL ;
AVNER, PR .
EMBO JOURNAL, 1985, 4 (13B) :3695-3700
[2]   CLONING OF THE HUMAN AND MOUSE TYPE-X COLLAGEN GENES AND MAPPING OF THE MOUSE TYPE-X COLLAGEN GENE TO CHROMOSOME-10 [J].
APTE, SS ;
SELDIN, MF ;
HAYASHI, M ;
OLSEN, BR .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 206 (01) :217-224
[3]   DETAILED ORDERING OF MARKERS LOCALIZING TO THE XQ26-ZQTER REGION OF THE HUMAN X-CHROMOSOME BY THE USE OF AN INTERSPECIFIC MUS-SPRETUS MOUSE CROSS [J].
AVNER, P ;
AMAR, L ;
ARNAUD, D ;
HANAUER, A ;
CAMBROU, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (06) :1629-1633
[4]   DISORDERS OF THE INHIBITORY GLYCINE RECEPTOR - THE SPASTIC MOUSE [J].
BECKER, CM .
FASEB JOURNAL, 1990, 4 (10) :2767-2774
[5]   CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT [J].
BETTLER, B ;
BOULTER, J ;
HERMANSBORGMEYER, I ;
OSHEAGREENFIELD, A ;
DENERIS, ES ;
MOLL, C ;
BORGMEYER, U ;
HOLLMANN, M ;
HEINEMANN, S .
NEURON, 1990, 5 (05) :583-595
[6]   CLONING OF A PUTATIVE GLUTAMATE RECEPTOR - A LOW AFFINITY KAINATE-BINDING SUBUNIT [J].
BETTLER, B ;
EGEBJERG, J ;
SHARMA, G ;
PECHT, G ;
HERMANSBORGMEYER, I ;
MOLL, C ;
STEVENS, CF ;
HEINEMANN, S .
NEURON, 1992, 8 (02) :257-265
[7]   REMARKABLE HOMOLOGY AMONG THE INTERNAL REPEATS OF ERYTHROID AND NONERYTHROID SPECTRIN [J].
BIRKENMEIER, CS ;
BODINE, DM ;
REPASKY, EA ;
HELFMAN, DM ;
HUGHES, SH ;
BARKER, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (17) :5671-5675
[8]  
BISHOP D T, 1985, Genetic Epidemiology, V2, P349, DOI 10.1002/gepi.1370020404
[9]  
Blank R, 1991, Mamm Genome, V1 Spec No, pS51, DOI 10.1007/BF00656486
[10]  
BODE VC, 1988, GENETICS, V118, P299
12345678