EPIDERMAL GROWTH-FACTOR RECEPTORS IN GENETICALLY INDUCED HYPERPROLIFERATIVE SKIN DISORDERS

被引：12

作者：

NANNEY, LB

KING, LE

DALE, BA

机构：

[1] Department of Plastic Surgery & Cell Biology, University of Washington, Seattle, Washington

[2] Department of Medicine (Dermatology), Vanderbilt University

[3] Department of Nashville, Tennessee

[4] Department of Biochemistry, University of Washington, Seattle, Washington

[5] Department of Medicine Dermatology, University of Washington, Seattle, Washington

[6] Veterans Administration Medical Center, University of Washington, Seattle, Washington

[7] Departments of Periodontics, University of Washington, Seattle, Washington

来源：

PEDIATRIC DERMATOLOGY | 1990年 / 7卷 / 04期

关键词：

D O I：

10.1111/j.1525-1470.1990.tb01021.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The presence and morphologic distribution of epidermal growth factor receptor (EGF-R) were investigated in a variety of genetic disorders that affect human epidermis. These diseases included various forms of ichthyoses as well as restrictive dermopathy and the CHILD syndrome (congenital hemidysplasia-ichthyosiform erythroderma-limb defects). The distribution of EGF-R was detected by immunohistochemical techniques. Increased staining of immunoreactive EGF-R was frequently, but not always, seen in lesions with experimental or clinical evidence of hyperproliferation, suggesting an increased potential to respond to endogenous levels of either transforming growth factor-alpha or EGF. The finding that EGF-R levels are not always increased in congenital epidermal disorders indicated that the presence of this receptor pathway is not simply a marker for aberrant epidermis.

引用

页码：256 / 265

页数：10

共 46 条

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