C-TYPE POTASSIUM CHANNELS IN THE LATERAL CELL-MEMBRANE OF GUINEA-PIG OUTER HAIR-CELLS

被引：26

作者：

GITTER, AH

FROMTER, E

ZENNER, HP

机构：

[1] UNIV TUBINGEN,HALS NASEN OHREN KLIN,SILCHERSTR 5,W-7400 TUBINGEN 1,GERMANY

[2] UNIV FRANKFURT,ZENTRUM PHYSIOL,W-6000 FRANKFURT 1,GERMANY

来源：

HEARING RESEARCH | 1992年 / 60卷 / 01期

关键词：

CELL MEMBRANE POTENTIAL DIFFERENCE; COCHLEA; ION CHANNELS; OUTER HAIR CELL; POTASSIUM PERMEABILITY;

D O I：

10.1016/0378-5955(92)90053-P

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The basolateral cell membrane of outer hair cells (OHC) from the mammalian cochlea is known to contain K+-channels. The prevailing type, a high-conductance K+-channel was further characterized in the present study in order to support its classification as C channel. OHC were isolated from the 3rd and 4th turn of the guinea-pig cochlea. Cell-attached and excised inside-out patches of the lateral cell membrane were investigated. The C-type channel had a selectivity for K+ over Na+ of 12:1 to 20:1 and displayed Goldman-type rectification and voltage-dependence of the open probability. The kinetics of both opening and closing could be described by time constants in the range of ms. The channel provides a calcium- and voltage-activated pathway through OHC lateral membranes for passive K+ transport.

引用

页码：13 / 19

页数：7

共 30 条

[1] VARIATION OF MEMBRANE-PROPERTIES IN HAIR-CELLS ISOLATED FROM THE TURTLE COCHLEA [J].

ART, JJ ;

FETTIPLACE, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 385 :207-&

[2] IONIC BASIS OF MEMBRANE-POTENTIAL IN OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA [J].

ASHMORE, JF ;

MEECH, RW .

NATURE, 1986, 322 (6077) :368-371

[3] STRUCTURE AND FUNCTION OF VOLTAGE-SENSITIVE ION CHANNELS [J].

CATTERALL, WA .

SCIENCE, 1988, 242 (4875) :50-61

[4]

COREY DP, 1983, J NEUROSCI, V3, P962

[5] AN ELECTRICAL TUNING MECHANISM IN TURTLE COCHLEAR HAIR-CELLS [J].

CRAWFORD, AC ;

FETTIPLACE, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1981, 312 (MAR) :377-412

[6] NEUROBIOLOGY OF COCHLEAR INNER AND OUTER HAIR-CELLS - INTRACELLULAR-RECORDINGS [J].

DALLOS, P .

HEARING RESEARCH, 1986, 22 (1-3) :185-198

[7]

DALLOS P, 1984, HEARING RES, V12, P89

[8]

DAVIS H, 1958, Ann Otol Rhinol Laryngol, V67, P789

[9]

FUCHS PA, 1988, J NEUROSCI, V8, P2460

[10] MEMBRANE-POTENTIAL AND ION CHANNELS IN ISOLATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA [J].

GITTER, AH ;

ZENNER, HP ;

FROMTER, E .

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 1986, 48 (02) :68-75

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