COMPARISON OF THE REACTIVITY OF MICROVESSELS AND MACROVESSELS TO NORADRENALINE AND ENDOTHELIN IN RATS WITH RENAL (2K1C) HYPERTENSION

被引：11

作者：

FORTES, ZB ^{[1
]}

COSTA, SG ^{[1
]}

NUCCI, G ^{[1
]}

NIGRO, D ^{[1
]}

SCIVOLETTO, R ^{[1
]}

CARVALHO, MHC ^{[1
]}

机构：

[1] UNIV ESTADUAL CAMPINAS,DEPT PHARMACOL,BR-13100 CAMPINAS,SP,BRAZIL

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1990年 / 12卷 / 01期

关键词：

2K1C hypertension; Endothelin; Noradrenaline; Vascular reactivity;

D O I：

10.3109/10641969009074719

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The response to noradrenaline and endothelin in isolated aortae in vitro and mesenteric microvessels in vivo - in situ was studied in 4-week 2K1C hypertensive rats. Enhanced reactivity to noradrenaline was observed in aortae with endothelium isolated from hypertensive rats, whereas in aortae without endothelium, noradrenaline induced similar responses in sham-operated control and hypertensive preparations. Endothelin responses were not altered in aortae with or without endothelium isolated from hypertensive rats. In mesenteric microvessels, both noradrenaline and endothelin evoked higher responses in 2K1C than in control animals. It is suggested that the enhanced reactivity observed could be involved in the maintainance of high blood pressure levels in 2K1C hypertension. The altered reactivity could be due to a dysfunction of the endothelial cells. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：47 / 61

页数：15

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