NEPHROTIC SYNDROME AND RAPID RENAL-FAILURE IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE

被引：21
|
作者：
MURPHY, G
TZAMALOUKAS, AH
LISTROM, MB
GIBEL, LJ
SMITH, SM
GARDNER, KD
机构：
[1] UNIV NEW MEXICO,SCH MED,ALBUQUERQUE,NM 87131
[2] VET ADM MED CTR,DEPT MED,ALBUQUERQUE,NM 87108
[3] VET ADM MED CTR,DEPT PATHOL,ALBUQUERQUE,NM 87108
[4] VET ADM MED CTR,DEPT UROL,ALBUQUERQUE,NM 87108
来源：
AMERICAN JOURNAL OF NEPHROLOGY | 1990年 / 10卷 / 01期
关键词：
Autosomal dominant polycystic kidney disease; Focal glomerular sclerosis; Hypertension; Nephrotic syndrome; Proteinuria; Renal biopsy; Renal failure;
D O I：
10.1159/000168057
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A 44-year-old man, with autosomal dominant polycystic kidney disease and hypertension under satisfactory control, developed nephrotic syndrome with negative serology. Open renal biopsy revealed focal glomerular sclerosis. Priorto the appearance of heavy proteinuria, serum creatinine was 1.7 mg/dl. After the nephrotic syndrome had been established, renal function deteriorated rapidly and hemodialysis was started within 2.6 years. In patients with autosomal dominant polycystic kidney disease, the appearance of nephrotic range proteinuria along with a rapid decline in renal function indicates the presence of a glomerular lesion, which needs to be investigated by renal biopsy. © 1990 S. Karger AG, Basel.
引用
收藏
页码：69 / 72
页数：4
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