CELLULAR-DIFFERENTIATION AND DIETARY-REGULATION OF GENE-EXPRESSION

被引：16
作者：
NTAMBI, JM
机构：
[1] Department of Biochemistry, The University of Wisconsin-Madison, Madison, WI 53706
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1995年 / 52卷 / 2-3期
关键词：
D O I：
10.1016/0952-3278(95)90009-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The differentiation of 3T3-L1 preadipocytes into adipocytes is one of the few well characterized model systems available to study cellular differentiation in culture. We cloned and determined the genetic organization of two murine stearoyl-CoA desaturase genes (SCD1 and SCD2), both of which are transcriptionally activated during preadipocyte differentiation, but are regulated differentially by diet in liver and other tissues, These genes are now being used as a model to study mechanisms of cellular differentiation, tissue-specific gene expression, and dietary regulation of gene expression, It is the objective of this article to provide a brief overview of some of the studies on the regulation of the SCD1 and SCD2 genes during 3T3-L1 preadipocyte differentiation, and also on their differential responses to dietary manipulations in liver tissue.
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收藏
页码：117 / 120
页数：4
相关论文
共 21 条
[11]   MOUSE INSULIN-RESPONSIVE GLUCOSE TRANSPORTER GENE - CHARACTERIZATION OF THE GENE AND TRANSACTIVATION BY THE CCAAT ENHANCER BINDING-PROTEIN [J].
KAESTNER, KH ;
CHRISTY, RJ ;
LANE, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :251-255
[12]  
KASTURI I, 1982, J BIOL CHEM, V257, P12224
[13]   TRANSCRIPTIONAL CONTROL OF THE STEAROYL-COA DESATURASE-1 GENE BY POLYUNSATURATED FATTY-ACIDS [J].
LANDSCHULZ, KT ;
JUMP, DB ;
MACDOUGALD, OA ;
LANE, MD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (02) :763-768
[14]   THE LEUCINE ZIPPER - A HYPOTHETICAL STRUCTURE COMMON TO A NEW CLASS OF DNA-BINDING PROTEINS [J].
LANDSCHULZ, WH ;
JOHNSON, PF ;
MCKNIGHT, SL .
SCIENCE, 1988, 240 (4860) :1759-1764
[15]  
NTAMBI JM, 1988, J BIOL CHEM, V263, P17291
[16]  
NTAMBI JM, 1992, J BIOL CHEM, V267, P10925
[17]   IDENTIFICATION OF A TRANSCRIPTIONAL REPRESSOR DOWN-REGULATED DURING PREADIPOCYTE DIFFERENTIATION [J].
SWICK, AG ;
LANE, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (17) :7895-7899
[18]  
THIEDE MA, 1985, J BIOL CHEM, V260, P4459
[19]  
THIEDE MA, 1986, J BIOL CHEM, V261, P3230
[20]   REPRESSION OF PENTOSE-PHOSPHATE PATHWAY DEHYDROGENASE SYNTHESIS AND MESSENGER-RNA BY DIETARY-FAT IN RATS [J].
TOMLINSON, JE ;
NAKAYAMA, R ;
HOLTEN, D .
JOURNAL OF NUTRITION, 1988, 118 (03) :408-415
123