SYNTHESIS OF CAGED COMPOUNDS OF L-LEUCYL-L-LEUCINE METHYL-ESTER, AN APOPTOSIS INDUCER, AND THEIR CYTOTOXIC ACTIVITY

被引：12

作者：

ODAKA, M ^{[1
]}

FURUTA, T ^{[1
]}

KOBAYASHI, Y ^{[1
]}

IWAMURA, M ^{[1
]}

机构：

[1] TOHO UNIV,FAC SCI,DEPT BIOMOLEC SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2181

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we newly synthesized caged compounds of L-leucyl-L-leucine methyl ester and examined their photochemical and immunological properties. From the viewpoints of solubility in phosphate-buffered saline containing 1% dimethyl sulfoxide as well as photoreactivity, we chose two caged compounds, 1 and 2, for study. Upon irradiation, L-leucyl-L-leucine methyl ester with a trans-o-hydroxycinnamoyl group (1) releases L-leucyl-L-leucine methyl ester quite slowly, whereas L-leucyl-L-leucine methyl ester with an o-nitrobenzyl group (2) releases L-leucyl-L-leucine methyl ester quickly. Both irradiated compounds induced apoptosis of U937 cells, as evidenced by a decrease in cell size, although 1 itself caused necrosis (cell swelling) of these cells. (C) 1995 Academic Press, Inc.

引用

页码：652 / 656

页数：5

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