ADMINISTRATION OF A GONADOTROPIN-RELEASING-HORMONE AGONIST DURING PREGNANCY - FOLLOW-UP OF 28 PREGNANCIES EXPOSED TO TRIPTORELINE

被引：26

作者：

ELEFANT, E ^{[1
]}

BIOUR, B ^{[1
]}

BLUMBERGTICK, J ^{[1
]}

ROUX, C ^{[1
]}

THOMAS, F ^{[1
]}

机构：

[1] IPSEN BIOTECH INC,TIPTORELINE,PARIS,FRANCE

来源：

FERTILITY AND STERILITY | 1995年 / 63卷 / 05期

关键词：

GNRH AGONIST; PREGNANCY; TERATOGENICITY;

D O I：

10.1016/S0015-0282(16)57557-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the teratogenic or fetal risk of a long-acting GnRH agonist (GnRH-a) triptoreline acetate (Decapeptyl; Ipsen-Biotech, Inc., Paris, France), inadvertently administrated in the first weeks of pregnancy. Design: Prospective follow-up of exposed pregnancies and case reports. Setting: Teratology information service of a public hospital and pharmacovigilance department of the firm. Patients: Inadvertent pregnant women receiving a treatment, mainly for endometriosis or IVF. Interventions: Case by case, individual estimations of the risks have been provided. Main Outcome Measure: Each pregnancy issue has been analyzed. Results: No teratogenic or fetal toxic effect has been noted. Conclusion: No specific hazard has been observed among newborns after inadvertent exposures to a GnRH-a during the first 20 weeks of pregnancy.

引用

页码：1111 / 1113

页数：3

共 5 条

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[J]. TERATOLOGY, 1992, 46 (01) : 35 - 44
[3] CASE-REPORT - ACCIDENTAL GNRH AGONIST ADMINISTRATION DURING EARLY-PREGNANCY
MARTINEZ, F
BARRI, PN
COROLEU, V
[J]. HUMAN REPRODUCTION, 1988, 3 (05) : 669 - 669
[4] WILSHIRE GB, 1993, FERTIL STERIL, V60, P980
[5] YOUNG DC, 1993, OBSTET GYNECOL, V81, P587

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