ASCORBIC-ACID INHIBITS PROTEIN-TYROSINE PHOSPHATASES IN NIH 3T3 CELLS EXPRESSING HUMAN EPIDERMAL GROWTH-FACTOR RECEPTORS

被引：14
|
作者：
MONTEIRO, HP
IVASCHENKO, Y
FISCHER, R
STERN, A
机构：
[1] NYU MED CTR,DEPT PHARMACOL,NEW YORK,NY 10016
[2] FDN HEMOCTR SAO PAULO,SAO PAULO,SP,BRAZIL
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 12期
关键词：
D O I：
10.1016/0020-711X(88)90317-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. Physiological concentrations of ascorbic acid inhibited PTPase activity in HER 14 cells. 2. Higher concentrations of ascorbic acid produced a weaker inhibitory effect on PTPase activity in HER 14 cells. 3. EGF prevented the inhibitory effect of ascorbic acid on PTPase activity in HER 14 cells. 4. The inhibitory effect of physiological concentrations of ascorbic acid on PTPase activity depends on density of the cell culture, with less dense populations exhibiting greater inhibition of PTPase activity. 5. These observations suggest that ascorbic acid might have a modulatory role in cellular phosphorylation-dephosphorylation events.
引用
收藏
页码：1859 / 1864
页数：6
相关论文
共 50 条
  • [1] COLCHICINE INHIBITS EPIDERMAL GROWTH-FACTOR DEGRADATION IN 3T3 CELLS
    BROWN, KD
    FRIEDKIN, M
    ROZENGURT, E
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (01): : 480 - 484
  • [2] EXPRESSION OF HUMAN EPIDERMAL GROWTH-FACTOR PRECURSOR CDNA IN TRANSFECTED MOUSE NIH 3T3 CELLS
    MROCZKOWSKI, B
    REICH, M
    WHITTAKER, J
    BELL, GI
    COHEN, S
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (01) : 126 - 130
  • [3] MODULATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS ON 3T3 CELLS BY PLATELET-DERIVED GROWTH-FACTOR
    WRANN, M
    FOX, CF
    ROSS, R
    SCIENCE, 1980, 210 (4476) : 1363 - 1365
  • [4] LIGAND ACTIVATION OF OVEREXPRESSED EPIDERMAL GROWTH-FACTOR RECEPTORS TRANSFORMS NIH 3T3 MOUSE FIBROBLASTS
    RIEDEL, H
    MASSOGLIA, S
    SCHLESSINGER, J
    ULLRICH, A
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) : 1477 - 1481
  • [5] RECEPTORS FOR EPIDERMAL GROWTH-FACTOR (EGF) AND FIBROBLAST GROWTH-FACTOR IN CHEMICAL TRANSFORMED MOUSE EMBRYO 3T3 CELLS
    YEH, YC
    HOLLEY, RW
    FEDERATION PROCEEDINGS, 1977, 36 (03) : 711 - 711
  • [6] THE DEPHOSPHORYLATION CHARACTERISTICS OF THE RECEPTORS FOR EPIDERMAL GROWTH-FACTOR AND PLATELET-DERIVED GROWTH-FACTOR IN SWISS 3T3-CELL MEMBRANES SUGGEST DIFFERENTIAL REGULATION OF RECEPTOR SIGNALING BY ENDOGENOUS PROTEIN-TYROSINE PHOSPHATASES
    BOHMER, FD
    BOHMER, SA
    HELDIN, CH
    FEBS LETTERS, 1993, 331 (03) : 276 - 280
  • [7] EPIDERMAL GROWTH-FACTOR INDUCED MEMBRANE CHANGES IN 3T3 CELLS
    AHARONOV, A
    VLODAVSKY, I
    PRUSS, RM
    FOX, CF
    HERSCHMAN, HR
    JOURNAL OF CELLULAR PHYSIOLOGY, 1978, 95 (02) : 195 - 202
  • [8] ORNITHINE DECARBOXYLASE TRANSFORMATION OF NIH/3T3 CELLS IS MEDIATED BY ALTERED EPIDERMAL GROWTH-FACTOR RECEPTOR ACTIVITY
    MOSHIER, JA
    MALECKAPANAS, E
    GENG, H
    DOSESCU, J
    TUREAUD, J
    SKUNCA, M
    MAJUMDAR, APN
    CANCER RESEARCH, 1995, 55 (22) : 5358 - 5365
  • [9] INHIBITION OF EPIDERMAL GROWTH-FACTOR RECEPTOR FUNCTIONS BY TYROSINE KINASE INHIBITORS IN NIH3T3 CELLS
    UMEZAWA, K
    SUGATA, D
    YAMASHITA, K
    JOHTOH, N
    SHIBUYA, M
    FEBS LETTERS, 1992, 314 (03): : 289 - 292
  • [10] DIACYLGLYCEROL TREATMENT RAPIDLY DECREASES THE AFFINITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTORS OF SWISS 3T3 CELLS
    SINNETTSMITH, JW
    ROZENGURT, E
    JOURNAL OF CELLULAR PHYSIOLOGY, 1985, 124 (01) : 81 - 86
12345