ISOLATION AND BIOLOGICAL-ACTIVITY OF ASPIDOSPERMINE AND QUEBRACHAMINE FROM AN ASPIDOSPERMA TREE SOURCE

被引：47

作者：

DEUTSCH, HF

EVENSON, MA

DRESCHER, P

SPARWASSER, C

MADSEN, PO

机构：

[1] UNIV WISCONSIN,SCH MED,DEPT BIOMOLEC CHEM,MADISON,WI 53705

[2] UNIV WISCONSIN,SCH MED,DEPT PATHOL LAB MED,MADISON,WI 53705

[3] UNIV WISCONSIN,SCH MED,DEPT SURG,MADISON,WI 53705

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 10期

关键词：

ASPIDOSPERMINE; QUEBRACHAMINE; INDOLEALKALOIDS; LIQUID CHROMATOGRAPHY;

D O I：

10.1016/0731-7085(94)00066-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The indolealkaloids aspidospermine and quebrachamine have been isolated in crystalline form by a relatively rapid fractionation from the extract of a powdered material designated ''Quebracho'' derived from an Aspidosperma tree species. We present a novel isocratic LC method that provides baseline resolution of these two compounds and of the structurally related yohimbine in less than 15 min. Gas chromatography-mass spectrometry was employed to identify these compounds as well as several minor derivatives of aspidospermine during and after the purification process. Aspidospermine and quebrachamine like yohimbine have been found to possess adrenergic blocking activities for a variety of urogenital tissues.

引用

页码：1283 / 1287

页数：5