FATE OF DIMETHYLAMINE IN RAT AND MOUSE

被引：6

作者：

ZHANG, AQ ^{[1
]}

MITCHELL, SC ^{[1
]}

SMITH, RL ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT PHARMACOL & TOXICOL,LONDON W2 1PG,ENGLAND

来源：

XENOBIOTICA | 1994年 / 24卷 / 12期

关键词：

D O I：

10.3109/00498259409038677

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. [U-C-14]-dimethylamine hydrochloride was administered by gavage (20 mu mol/kg body weight) to adult male Wistar rat and CD1 strain mouse. 2. In both species, urine was the main route of excretion with the majority of radiolabel (91%) being voided during the first day. Additional small amounts of radioactivity were detected in the 24-72 h urine (2%), in faeces (2%) and amidst exhaled air (1%), with minor amounts remaining within the carcass (1%) after 3 days. 3. Metabolism was limited to demethylation, with the majority of the compound (89% dose; 96% urinary radioactivity) being excreted unchanged.

引用

页码：1215 / 1221

页数：7

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