HEMATOPOIETIC GROWTH-FACTORS FOR ANTITHYROID DRUG-INDUCED AGRANULOCYTOSIS

被引：0
|
作者：
GENET, P [1 ]
PULIK, M [1 ]
LIONNET, F [1 ]
BREMONT, C [1 ]
机构：
[1] HOP VICTOR DUPOUY,SERV ENDOCRINOL,F-95107 ARGENTEUIL,FRANCE
来源：
ANNALES D ENDOCRINOLOGIE | 1994年 / 55卷 / 01期
关键词：
ANTITHYROID DRUGS; AGRANULOCYTOSIS; G-CSF; GMCSF;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Agranulocytosis is the most serious problem, potentially fatal, that can occur during antithyroid drug therapy. The use of hematopoietic growth factors is an attractive approach to reduce the period of this drug-induced neutropenia. We report two cases of severe antithyroid drug-related agranulocytosis (granulocyte count < 0.1 X 10(9)/L) treated with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). The delay to observe a granulocyte count superior to 1 X 10(9)/L was respectively 1 and 5 days. Our results, with others, clearly show that hematopoietic growth factors are effective in severe antithyroid drug-induced agranulocytosis.
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收藏
页码：39 / 42
页数：4
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