PROTEINS REGULATING RAS AND ITS RELATIVES

被引：1791

作者：

BOGUSKI, MS ^{[1
]}

MCCORMICK, F ^{[1
]}

机构：

[1] ONOX PHARMACEUT, RICHMOND, CA 94806 USA

来源：

NATURE | 1993年 / 366卷 / 6456期

关键词：

D O I：

10.1038/366643a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and action. Their functions depend on their ability to alternate between inactive and active forms, and on their cellular localization. Numerous proteins affecting the GTPase activity, nucleotide exchange rates and membrane localization of Ras superfamily members have now been identified. Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.

引用

页码：643 / 654

页数：12

共 127 条

[1] A DROSOPHILA ROTUND TRANSCRIPT EXPRESSED DURING SPERMATOGENESIS AND IMAGINAL DISK MORPHOGENESIS ENCODES A PROTEIN WHICH IS SIMILAR TO HUMAN RAC GTPASE-ACTIVATING (RACGAP) PROTEINS [J].