DRUG-INDUCED LYMPHOCYTIC COLITIS

被引：103
|
作者：
BEAUGERIE, L
LUBOINSKI, J
BROUSSE, N
COSNES, J
CHATELET, FP
GENDRE, JP
LEQUINTREC, Y
机构：
[1] HOP ROTHSCHILD,DEPT PATHOL,F-75571 PARIS 12,FRANCE
[2] HOP NECKER ENFANTS MALAD,DEPT PATHOL,F-75730 PARIS 15,FRANCE
来源：
GUT | 1994年 / 35卷 / 03期
关键词：
D O I：
10.1136/gut.35.3.426
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient where the immunopathological features of mucosal immune cell activation were induced by drug rechallenge. It is concluded that lymphocytic colitis may be drug induced, secondary to a chronic activation of the mucosal immune system by one or several components of the drug.
引用
收藏
页码：426 / 428
页数：3
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