CYTOTOXIC DITERPENOIDS FROM THE BROWN ALGA DILOPHUS-LIGULATUS

被引：16

作者：

BOUAICHA, N ^{[1
]}

PESANDO, D ^{[1
]}

PUEL, D ^{[1
]}

机构：

[1] UNIV CATANIA,DIPARTIMENTO SCI CHIM,I-95125 CATANIA,ITALY

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 10期

关键词：

D O I：

10.1021/np50100a013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new xenicane-type diterpene, dilopholide [5], and four known diterpenoids, acetoxycrenulide [1), acetylcoriacenone [2), and its epimer isoacetylcoriacenone [3], and hydroxyacetyldictyolal [4], have been isolated from the brown alga Dilophus ligulatus [syn. spiralis (Montagne) Hamell. The structure of dilopholide [5] was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques, including H-1-H-1 COSY, heteronuclear proton-carbon chemical shift correlation (HETCOSY), and long-range HETCOSY. The cytotoxic activity of compounds 1-5 has been examined against several types of mammalian cells: human nasopharynx carcinoma cells (KB), human lung carcinoma cells (NSCLC-N6), murine leukemia cells (P-388), and murine leukemia cells expressing the multi-drug-resistance gene, mdr (P-388/DOX).

引用

页码：1747 / 1752

页数：6

共 12 条

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