CARBON-DIOXIDE INHALATION REDUCES THE FUNCTION OF GABA-A RECEPTORS IN THE RAT-BRAIN

被引：36
|
作者：
SANNA, E
CUCCHEDDU, T
SERRA, M
CONCAS, A
BIGGIO, G
机构：
[1] Department of Experimental Biology, University of Cagliari
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 03期
关键词：
CARBON DIOXIDE (CO2); GABA-A RECEPTORS; BRAIN (RAT);
D O I：
10.1016/0014-2999(92)90447-C
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of CO2 inhalation on the function of the GABA(A)-coupled chloride channel was evaluated in rat brain. This treatment decreased the capability of GABA to stimulate Cl-36 uptake and produced a significant increase of [S-35]-TBPS ([S-35]t-butylbicyclophosphorothionate) binding in the cerebral cortex, cerebellum and hippocampus. These results demonstrate that a brief exposure of rats to CO2 inhalation reduces the function of the GABA(A)-ionophore receptor complex in rat brain.
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页码：457 / 458
页数：2
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