CARBON-DIOXIDE INHALATION REDUCES THE FUNCTION OF GABA-A RECEPTORS IN THE RAT-BRAIN

被引：36
|
作者：
SANNA, E
CUCCHEDDU, T
SERRA, M
CONCAS, A
BIGGIO, G
机构：
[1] Department of Experimental Biology, University of Cagliari
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 03期
关键词：
CARBON DIOXIDE (CO2); GABA-A RECEPTORS; BRAIN (RAT);
D O I：
10.1016/0014-2999(92)90447-C
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of CO2 inhalation on the function of the GABA(A)-coupled chloride channel was evaluated in rat brain. This treatment decreased the capability of GABA to stimulate Cl-36 uptake and produced a significant increase of [S-35]-TBPS ([S-35]t-butylbicyclophosphorothionate) binding in the cerebral cortex, cerebellum and hippocampus. These results demonstrate that a brief exposure of rats to CO2 inhalation reduces the function of the GABA(A)-ionophore receptor complex in rat brain.
引用
收藏
页码：457 / 458
页数：2
相关论文
共 28 条
  • [1] DIFFERENTIAL-EFFECTS OF OLFACTORY BULBECTOMY ON GABA-A AND GABA-B RECEPTORS IN THE RAT-BRAIN
    DENNIS, T
    BEAUCHEMIN, V
    LAVOIE, N
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 46 (01) : 77 - 82
  • [2] LOCALIZATION OF GABA-A RECEPTORS IN THE RAT RETINA
    GREFERATH, U
    MULLER, F
    WASSLE, H
    SHIVERS, B
    SEEBURG, P
    VISUAL NEUROSCIENCE, 1993, 10 (03) : 551 - 561
  • [3] CEREBELLAR GABA-B RECEPTORS MODULATE FUNCTION OF GABA-A RECEPTORS
    HAHNER, L
    MCQUILKIN, S
    HARRIS, RA
    FASEB JOURNAL, 1991, 5 (10): : 2466 - 2472
  • [4] EARLY POSTNATAL TREATMENT WITH MUSCIMOL TRANSIENTLY ALTERS BRAIN GABA-A RECEPTORS AND OPEN-FIELD BEHAVIOR IN RAT
    TAIRA, T
    UUSIOUKARI, M
    KORPI, ER
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 230 (03) : 307 - 312
  • [5] PH TRANSIENTS DUE TO MONOSYNAPTIC ACTIVATION OF GABA-A RECEPTORS IN RAT HIPPOCAMPAL SLICES
    KAILA, K
    PAALASMAA, P
    TAIRA, T
    VOIPIO, J
    NEUROREPORT, 1992, 3 (01) : 105 - 108
  • [6] PTBR activation and increase of agonists of GABA-A receptors at the neurosteroid site in brain in hepatic encephalopathy
    Ahboucha, S
    Desjardins, P
    Chatauret, N
    Pomier-Layrargues, G
    Butterworth, RF
    JOURNAL OF NEUROCHEMISTRY, 2003, 87 : 61 - 61
  • [7] ELECTRIC-SHOCK CONVULSIONS IN THE RABBIT AND BRAIN CORTEX GABA-A RECEPTOR FUNCTION
    CUPELLO, A
    PATRONE, A
    ROBELLO, M
    VIGNOLO, L
    LOEB, C
    NEUROCHEMICAL RESEARCH, 1993, 18 (08) : 883 - 886
  • [8] GONADAL REGULATION OF GABA-A RECEPTORS IN THE DIFFERENT BRAIN-AREAS OF THE MALE JAPANESE-QUAIL
    CANONACO, M
    TAVOLARO, R
    CERRA, MC
    ANASTASIO, M
    FRANZONI, MF
    EXPERIMENTAL BRAIN RESEARCH, 1991, 87 (03) : 634 - 640
  • [9] SODIUM-CHANNELS, GABA-A RECEPTORS, AND GLUTAMATE RECEPTORS DEVELOP SEQUENTIALLY ON EMBRYONIC RAT SPINAL-CORD CELLS
    WALTON, MK
    SCHAFFNER, AE
    BARKER, JL
    JOURNAL OF NEUROSCIENCE, 1993, 13 (05): : 2068 - 2084
  • [10] REGIONAL DISTRIBUTION OF LOW-AFFINITY GABA RECEPTORS COUPLED TO BENZODIAZEPINE RECEPTOR SUBTYPES IN RAT-BRAIN - AN AUTORADIOGRAPHIC EVALUATION
    MENNINI, T
    GOBBI, M
    EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1990, 189 (2-3): : 143 - 148
123